Research Interests:

perioperative hemodynamic, metabolic, coagulation and fibrinolytic changes during liver transplantation, the relationship between intraoperative changes and short-term outcome or postoperative complications in general anesthesia, cardiovascular or neurological monitoring during general anesthesia, and the anesthesia perioperative database

Dr. Xia received his M.D. at the Tongji Medical University, Wuhan, China. He was a postdoctoral research fellow at Harvard Medical School and UCSF, where he worked on transplantation and cancer immunology. He received his resident training at the University of Iowa Hospitals and Clinics. Since joining the clinical faculty at UCLA, his clinical responsibility includes both general anesthesia and liver transplantation anesthesia. He is also actively involved in clinical anesthesia research.

Publications:

1. Xia W, et al. Histological observation of total and segmental small bowel transplantation in the rat. Chinese J Organ Transplant 1986; 7:8
2. Xia W and Xia S. Orthotopic and herterotopic small bowel transplantation in the rat. Chinese J Organ Transplant 1987; 8:61
3. Xia W and Xia S. Orthotopic and heterotopic small bowel transplantation in rats. Chinese Med Journal (English) 1988; 101:13
4. Xia W, et al. Partial spenic embolization through surgical approach in the dog. Chinese J Exp Surgery 1989; 6:13
5. Xia W and Kirkman RL. Immune function in transplanted small intestine: total secretary IgA production and response against cholera toxin. Transplantation 1990: 49:277
6. Xia W and Kirkman RL. Immune function in transplanted small intestine II: sIgA production in cholera toxin primed rats. Transplant Pro 1990; 22:2481
7. Xia W and Kirkman RL. Inhibitory effect of cyclosporine on specific secretary IgA production against cholera toxin in small bowel transplantation. Transplant Proc 1991; 23:682
8. Xia W and Kirkman RL. Cyclosporine A inhibits specific sIgA production against cholera toxin but not trinitrophynyllipopolysacchride (TNP-LPS) in small bowel transplantation. Transplant Proc 1992; 24:1155
9. Xia W and Kirkman RL. Priming the recipient abrogates the inhibitory effect of cyclosporine on specific sIgA production against cholera toxin in small bowel transplantation. Transplant Proc 1992; 24:1139
10. Xia W, Fearon DT, Moore FD, Schoen FJ, Ortis F and Kirkman RL. Prolongation of guinea pig cardiac xenograft survival in rats by soluble human complement receptor type 1. Transplant Proc 1992; 24:479
11. Xia W, Fearon DT and Kirkman RL. Effects of repetitive doses of soluble human complement receptor type 1 on survival of discordant cardiac xenografts. Transplant Proc 1993; 25:410
12. Xia W, Sayegh MH and Kirkman RL. Intrathymic injection of allogeneic cells induces indefinite survival of cardiac but small bowel grafts. Transplant Proc 1994: 26:1581
13. Xia W, Brandeis JM, Sayegh MH and Kirkman RL. Mesenteric and intraepithelial lymphocytes are insufficient to cause rejection but able to mediate lethal GVHD in small bowel transplants. Transplant Proc 1994: 26:1508
14. Xia W, Jablons DM and Cameron RB. Presentation of tumor antigens by peripheral blood derived dendrtic cells in patients with lung cancer. Surg Forum 1998: 49:432
15. Khan J, Xia W, Varricchio F, Puri R and Jablons DM, Interleukin-4 receptor expression marks malignant behavior of human pleural tumors. Surg Forum 1998: 49:269
16. Hu K, Lee S, Hu S, Xia V, Hillebrand D, and Kyulo N. Clinical presentation of chronic hepatitis C in patients with end-stage renal disease and on hemodialysis versus those with normal renal function. Am J Gastroen 2005; 100:2010
17. Xia V, Du B, Braunfeld M, Neelakanta G, Hu K, Nourmand H, Levin P, Enriquez R, Hiatt J, Ghobrial M, Farmer D, Busuttil R and Steadman R. Preoperative characteristics and intraoperative transfusion and vasopressor requirements in patients with low versus high MELD scores. Liver Transpl 2006; 12: 614
18. Xia V, Messerlian A, Mackley J, Calmes S, and Matevosian R. Successful epidural anesthesia for cesarean section in a parturient with severe aortic stenosis and a recent history of pulmonary edema—a case report. J Clin Anesth 2006; 18: 142
19. Xia V, Fond A, and Du B. Ascites, but not hyponatremia, is associated with high intraoperative transfusion and vasopressor requirements during liver transplantation. Transp Proc 2006; 38: 1398
20. Xia V, Du B, Tran A, Liu L, Hu K, Hiatt J, Busuttil R and Steadman R. Intraoperative hypokalemia in pediatric liver transplantation: incidence and risk factors. Anesth Analg 2006; 103:587
21. Xia V, Ghobrial RM, Du B, Chen T, Hu KQ, Hiatt HR, Busuttil RW and Steadman RH. Predictors of hyperkalemia in the prereperfusion, early postreperfusion and late postreperfusion periods during adult liver transplantation. Anesth Analg 2007; 105:780

1. Xia W and Xia S. Small bowel transplantation-a review. World Medicine (Chinese) 1985; 5:271
2. Xia W and Xia S. Surgical treatment of short bowel syndrome-a review. Wuhan Medicine (Chinese) 1986; 10:119
3. Xia W and Xia S. Partial splenic embolization and its application in surgery-a review. World Medicine (Chinese) 1987; 6:24
4. Xia V and Steadman R. Antifibrinolytics in orthotopic liver transplantation: current status and controversies. Liver Transpl 2005;11:10-18.

1. Xia W and Kirkman RL. Mucosal immunity of transplanted small bowel. In: Grand D. ed. Small bowel transplantation. London: P. 43. 1993 Edward Arnold (Publishers) Ltd.

1. Jablons DM, Cameron RM, Xia W, Varricchio F, Leland P, Kreitman R, Pastan I and Puri RK. Detection of IL-4 receptors on human mesothelioma and demonstration of specific cytotoxicity by a recombinant IL-4 pseudomonas extoxin against human mesothelioma cell lines. Chest 1997; 112:115.
2. Jablons DM, Cameron RM, Xia W, Leland P, Varricchio F and Puri RK. In vitro and in vivo expression of IL-4 receptors on human malignant mesothelioma: implication for therapy. The 88th Annual Meeting of American Association of Cancer Research Proceedings. P. 631, April 12-16, 1997.
3. Jablons DM, Xia W, Cameron RB, Varricchio F, Lelan P, Kreitman R, Pastan I and Puri R. Specific cytotoxicity of a recombinant IL-4 pseudomonas exotoxin against human mesothelial cell lines and implications for therapy. April 1998.
4. Khan J, Xia W, Varrichio F Puri R and Jablons DM. IL-4 receptor expression marks malignant behavior of human pleura tumors. American College of Chest Physicians, May 1998.
5. Xia V, Liu L, Tran A, Hu K, Kyulo N, Busuttil R and Steadman R. Intraoperative potassium disturbances are common in patients undergoing liver retransplantation. Liver Transpl 2004; 10:C-37.
6. Xia V, Liu L, Tran A, Hu K, Kyulo N, Hiatt J, Busuttil R and Steadman R. Intraoperative potassium disturbances in pediatric patients undergoing orthotopic liver transplantation-a retrospective study of consecutive 219 cases in a single center. Anesthesiology 2004; 101:A1436.
7. Hu K, Kyulo N, Hillebrand D, Xia V and Yu C. Factors associated with HCV-stage III/IV fibrinolysis: a retrospective study of a large cohort of US patients. Presented at Digestive Disease Week 2004, New Orleans, LA, 2004
8. Hu K, Lee S, Kyulo N, Hillebrand D, Xia V and Hu S. A comparative study on natural history of chronic hepatitis C in patients with chronic renal failure (CRF) vs normal renal function (NRF). Presented at Digestive Disease Week 2004, New Orleans, LA 2004
9. Kelly N, Tran A, Du B, Hu K, Steadman R, and Xia V. Intraoperative potassium disturbances during primary orthotopic liver transplantation in patients age 50 and older-- a single center retrospective study of 406 cases. Liver Transpl 2005; 11:C39.
10. Tran A, Steadman R, Hiatt J, Busuttil R, and Xia V. Hyperkalemia and Massive Blood Transfusion in Adult Liver Transplantation. Presented by 2005 ASA Annual Meeting, Atlanta, GA 2005
11. Hoang H, Kyulo N, Xia V, Hoefs J, Bui L, Wu M and Hu K. Different clinical presentation and treatment response of chronic hepatitis C in Asian Americans versus non-Asian Americans. Presented at 2005 AASLD Annual Meeting, San Francisco, CA
12. Xia V, Du B, Braunfeld M, Hu K, Neelakanta K, Nourmand H, Levin P, Enriquez R, Hiatt J, Busuttil R, Steadman R. Do patients with higher pretransplant MELD scores have higher intraoperative risks during liver transplant surgery? Presented at IARS 80th Clinical and Scientific Congress, San Francisco, CA 2006
13. Du B, Steadman R, Hu Q, Xia V. Prereperfusion hyperkalemia and risk factor analysis in 1134 cases of adult liver transplantation. Presented at IARS 80th Clinical and Scientific Congress, San Francisco, CA 2006
14. Fond A, Du B, Hu KQ and Xia V. Is hyponatremia associated with increased perioperative risks in the MELD era? Liver Transpl 2006; 12: C158
15. Mellen JS, Kyulo NL, Xia V, Hoefs J, Imagawa D and Hu KQ. The natural history of chronic hepatitis B virus (HBV) infection in Asian Americans: a retrospective single center study. Presented at American Association for the Study of Liver Diseases Digestive Disease Week Meeting 2006, Los Angeles, CA
16. Xia V, Ghobrial RM, Neelakanta G, Hu KQ, Busuttil RW and Steadman RH. Are extended criteria donors associated with higher potassium levels in adult liver transplantation? Presented at 2006 ASA Annual Meeting, Chicago, IL 2006
17. Xia V, Hu KQ, Hiatt HR, Busuttil RW, and Steadman RH. Predictors of postreperfusion hyperkalemia in adult liver transplantation: the impact of donors. Presented at International Liver Transplant Society Annual Meeting, Rio De Janeiro, Brazil 2007
18. Xia V, Messerlian A, and Matevosian R. A successful program that modifies Anesthesiologist’s Practice Pattern and Decreases the Incidence of PONV American Society of Anesthesiologists Annual Meeting, San Francisco, CA 2007
19. Lim H, Hsu C, Braunfeld M, Steadman R, and Xia V. Both Recipient and Donor Affect Postreperfusion Transfusion Requirements in Liver Transplantation. American Society of Anesthesiologists Annual Meeting, San Francisco, CA 2007

1. Myrick S, Chen T and Xia V. Effects of donor characteristics on blood transfusion during orthotopic liver transplantation. Presented at UCLA Medical Student Research Day, 2006
2. Obaidi M and Xia V. Comparison of targeted and conventional treatments of intraoperative hyperkalemia in liver transplantation. Presented at UCLA Medical Student Research Day, 2007