Portrait - Linda Cai
   Dr. H. Linda Cai, MD, PhD
   Chief Investigator
   Cai Laboratory

   Email: hcai@mednet.ucla.edu
   Phone: (310) 267-2303
   Fax: (310) 825-0132

   UCLA
   David Geffen School of Medicine
   Department of Anesthesiology
   Division of Molecular Medicine
   10833 Le Conte Ave
   BOX 951778, BH - 550 CHS
   Los Angeles, CA 90095-1778
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Recent Representative Publications:
(Six additional manuscripts are currently in preparation or under review for publications during the 2009-2010 academic year.)

For More Publications, See: Pub Med

  1. Shuvaev VV, Christofidou-Solomidou M, Bhora F, Laude K, Cai H, Dikalov S, Arguiri E, Solomides CC, Albelda SM, Harrison D, Muzykantov VR. Targeted detoxification of selected reactive oxygen species in the vascular endothelium. J Pharmacol Exp Ther. (2009) Aug 19.
    2. [Epub ahead of print]

  2. Gao L, Chalupsky K, Stefani E, Cai H. Mechanistic Insights into Folic Acid-dependent Vascular Protection: Dihydrofolate reductase-mediated Reduction in Oxidant Stress in Endothelial Cells and Angiotensin II-Infused Mice. A Novel HPLC-based Fluorescent Assay for DHFR Activity. J. Mol Cell Cardiol. (2009) In-press.

  3. Zhuo ML, Huang Y, Chen JZ, Sun LH, Yang RF, Chen HZ, Lv X, Li HL, Wei YS, Liu G, Zhang R, Ma TM, Cai H, Hui RT, Liu DP, Liang CC. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. Cardiovasc Res. (2009) Jul 23.
    4. [Epub ahead of print]

  4. Gao L, Pung YF, Zhang J, Chen P, Wang T, Li M, Meza M, Toro L, Cai H. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am. J. Physiol. Heart Circ. Physiol. (2009) Jul;297(1):H331-9.
    5. [Abstract & Full Text]

  5. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. (2009) May 1. pii: 38151. doi: 10.1172/JCI38151.
    6. [Epub ahead of print]

  6. Youn JY, Wang T, Cai H. An Ezrin/Calpain/PI3K/AMPK/AKT/eNOSs1179 Signaling Cascade Mediating VEGF-dependent Endothelial Nitric Oxide Production. Circulation Research (2009);104:50-59
    7. [Abstract & Full Text]

  7. Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res. (2008) Nov 1;80(2):191-9.
    8. [Abstract & Full Text]

  8. Cai H, Dikalov S, Griendling KK, Harrison DG. Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity. Methods Mol Med (2007);139:293-311.
    9. [Abstract & Full Text]

  9. Cai H, Liu DP, Garcia JG. CaM kinase II-dependent pathophysiological signaling in endothelial cells. Cardiovasc. Res. (2008) Jan;77(1):30-4.
    10. [Abstract & Full Text]

  10. Li HL, Zhou ML, Wang D, Wang AB, Cai H, Sun LH, Yang Q, Huang Y, Wei YS, Liu DP, Liang CC. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation (2007) Apr 10;115(14):1885-94.
    11. [Abstract & Full Text]

  11. Oak JH, Cai H. Attenuation of angiotensin II signaling recouples eNOS and inhibits non-endothelial NOX activity in diabetic mice. Diabetes (2007) Jan 56(1):118-126
    12. [Abstract & Full Text]

  12. Zhang G, Zhang F, Muh, R, Yi F, Chalupsky K, Cai H, Li PL. Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial myocytes. Am. J. Physiol. Heart Circ. Physiol. (2007) Jan; 292(1): H483-95
    13. [Abstract & Full Text]

  13. Nguyen A, Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci U S A. (2006) Track II, Apr 25;103(17):6530-5
    14. [Abstract & Full Text]

  14. Cai H. Potassium channel as endothelial mechanosensor and modulator of NAD(P)H oxidase: new mechanism for flow-mediated vasoprotection. (2006) Am J Physiol. Cell Physiol. Jan;290(1):C35-6
    15. [Full Text]

  15. Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, Tkachuk V, Berk BC. Urokinase stimulates vascular smooth muscle proliferation via redox-sensitive pathways. (2006) Arterioscler. Thromb. Vasc. Biol. 26(4):801-7
    16. [Abstract & Full Text]

  16. Cai H. Hydrogen peroxide regulation of endothelial function: Origins, mechanisms and consequences. (2005) Cardiovasc. Res. 68(1):26-36
    17. [Abstract & Full Text]

  17. Chalupsky K & Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of eNOS. Proc Natl Acad Sci U S A. Track II (2005) 102(25):9056-61
    18. [Abstract & Full Text]

  18. Cai H. NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease. (2005) Circ. Res. 96(8): 818-22
    19. [Abstract & Full Text]

  19. Nakagawa K, Oak JH, Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H, Miyazawa T. Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes. (2005) J Lipid Res. Nov;46(11):2514-24.
    20. [Abstract & Full Text]

  20. McNally JS, Saxena A, Cai H, Dikalov S, Harrison DG. Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium. Arterioscler Thromb Vasc Biol. (2005) Aug;25(8):1623-8.
    21. [Abstract & Full Text]

  21. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy S, Gamez G, Griendling KK, Harrison DG. Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. (2005) Am J Physiol Heart Circ Physiol. 288(1):H7-12
    22. [Abstract & Full Text]

  22. Nguyen A, Chen P, Cai H. Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells. (2004) FEBS Lett. 13;572(1-3):307-13
    23. [Abstract & Full Text]

  23. Searles CD, Ide L, Davis ME, Cai H, Weber M. Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. (2004) Circ. Res. 95(5):488-95
    24. [Abstract & Full Text]

  24. Cai H, McNally JS, Weber M, Harrison DG. Oscillatory shear stress regulation of endothelial cellsnitric oxide synthase requires intracellular hydrogen peroxide and CaMKII. (2004) J. Mol. Cell. Cardiol. 37:121-125
    25. [Abstract & Full Text]

  25. Harrison DG & Cai H. Endothelium control of vasomotion and nitric oxide production. (2003) Cardiology Clinics 21:289-302.
    26. [Review]

  26. Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular disease. (2003) Trends in Pharmacological Science, 24:471-8.
    27. [Abstract & Full Text]

  27. Harrison DG, Cai H, Landmesser U, Griendling KK,. Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. (2003) The Journal of the Renin-Angiotensin-Aldosterone System 4:51-61.
    28. [Abstract]

  28. Davis ME, Cai H, McCann L, Fukai T, Harrison DG. Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. (2003) Am. J. Physiol. Heart Circ. Physiol. 284:H1449-H1453.
    29. [Abstract & Full Text]

  29. Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Dudley SC. Akt-dependent phosphorylation of serine 1179 and MEK/ERK 1/2 cooperatively mediates the activation of endothelial nitric oxide synthase by hydrogen peroxide. (2003) Molecular Pharmacology 63:325-331.
    30. [Abstract & Full Text]

  30. Cai H, Li Z, Dikalov S, Holland SM, Hwang J, Jo H, Dudley SC, Harrison DG. NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production of in response to angiotensin II. (2002) J. Biol. Chem. 277:48311-48317.
    31. [Abstract & Full Text]

  31. Cai H, Li Z, Goette A, Mera F, Honeycutt C, Feterik K, Dudley SC, , Harrison DG, Langberg JJ. Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation. Potential mechanisms for atrial thombosis and stroke. (2002) Circulation 106:2854-2858.
    32. [Abstract & Full Text]

  32. Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, Holland SM, Harrison DG. Role of p47phox in vascular oxidative stress and hypertension caused by angiotensin II. (2002) Hypertension 40:511-515.
    33. [Abstract & Full Text]

  33. Davis ME, Cai H, Drummond GR, Harrison DG. Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways. (2001) Cir. Res. 89:1073-1080.
    34. [Abstract & Full Text]

  34. Cai H, Davis ME, Drummond GR, Harrison DG. Induction of endothelial NO synthase by hydrogen peroxide via a Ca2+/camodulin-dependent protein kinase II/janus kinase 2-dependent pathway. (2001) Arterioscler Thromb Vasc Biol. 21:1571-1576.
    35. [Abstract & Full Text]

  35. Cai H & Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. (2000) Cir. Res. 87:840-844.
    36. [Abstract & Full Text]

  36. Chan DK, Mellick G, Cai H, Wang XL, Ng PW, Pang CP, Woo J, Kay R. The alpha-synuclein gene and Parkinson disease in a Chinese population. (2000) Arch Neurol. Apr;57(4):501-3
    37. [Abstract & Full Text]

  37. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. (2000) Cir. Res. 86:347-354.
    38. [Abstract & Full Text]

  38. Cai H, Wang XL, Wilcken DE. Genetic polymorphism of heparan sulfate proteoglycan (perlecan, HSPG2), lipid profiles and coronary artery disease in the Australian population. (2000) AtherosclerosisJan;148(1):125-9
    39. [Abstract & Full Text]

  39. Wang XL, Duarte N, Cai H, Adachi T, Sim AS, Cranney G, Wilcken DE. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. (1999) AtherosclerosisSep;146(1):133-40
    40. [Abstract & Full Text]

  40. Cai H, Wilcken DE, Wang XL. The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. (1999) J Mol Med.Jun;77(6):511-4
    41. [Abstract & Full Text]

  41. Cai H, Duarte N, Wilcken DEL, Wang XL. NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population. (1999) Eur. J. Clin. Invest 29:744-748.
    42. [Abstract]

  42. Wang XL, Cai H, Cranney G, Wilcken DE. The frequency of a common mutation of the methionine synthase gene in the Australian population and its relation to smoking and coronary artery disease. (1998) J Cardiovasc RiskOct-Dec;5(5-6):289-95
    43. [Abstract & Full Text]

  43. Cai H, Wilcken DEL, Wang XL. The Glu298® Asp (984G® T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. (1999) J. Mol. Med. 77:511-514.


  44. Cai H, Wang X, Colagiuri S, Wilcken DE. Methionine synthase D919G mutation in type 2 diabetes and its relation to vascular events. (1998) Diabetes Care Oct;21(10):1774-5.
    45. [Abstract & Full Text]

Invited Book Chapters:

  1. Gao L, Laude K, Cai H. Mitochondrial Pathophysiology, Reactive Oxygen Species, and Cardiovascular Diseases. Veterinary Clinics of North America: Small Animal Practice; In-press
    2. [Abstract & Full Text]

  2. Cai H, Dikalov S. Griendling KK, Harrison DG. Detection of reactive oxygen species and nitric oxide in vascular cells: Comparison of sensitivity and specificity. In Vascular Biology Protocols, Editors: N Sreejaya and Ren J, Methods in Molecular Medicine, Humana Press Inc., New York, (2007), pg293-314
    3. [Full Text]
Copyright 2007